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News from our Network

2024-11-20

New Therapeutic Strategies for Pulmonary Fibrosis

International Lung Researchers, led by DZL Scientist Jürgen Behr, reach consensus on fundamental classifications for the treatment of Interstitial Lung Diseases. The article was published now in the American Journal of Respiratory and Critical Care Medicine.

2024-11-11

New blood test for treating malignant melanoma: liquid biopsy could complement radiological diagnostics

# DKTK

A relatively new blood test - the liquid biopsy - can provide information on whether the tumor in patients suffering from malignant melanoma is receding at a much earlier stage. In a study, researchers from Tübingen were able to show that liquid biopsy can supplement complex radiological diagnostics for skin cancer.

2024-11-04

3rd Long COVID Congress: Needs-based care for post-infectious diseases - a generational problem?

# DZG

The Long COVID Medical Association and the Federal Ministry of Health invite you to the 3rd Long COVID Congress in Berlin on November 25, 2024. Research results from the German Centers for Health Research will also be presented.

2024-10-30

How stigmatisation harms the psyche: The DZPG is researching ways to reduce stigma in society

#DZPG

People with mental illness are still stigmatized and therefore excluded and disadvantaged. The consequences for those affected can be serious. The DZPG has set itself the task of researching stigma and finding ways to reduce it.

2024-09-09

New risk score for assessing the risk of asthma in children

#DZL

Asthma in children is difficult to predict. However, a new risk score gives hope. Prof. Bianca Schaub from the DZL led a study combining molecular markers, epidemiological factors and allergic symptoms to provide a more precise prognosis.

2024-08-29

Successful research in first comprehensive study of the genome and proteome

#DKTK

Multiple myeloma is a form of cancer in which the immune cells in the bone marrow mutate and become cancerous. Researchers have now described in the journal Nature Cancer how particularly aggressive tumour variants can be detected at an early stage.

2024-08-16

Stable plaques, fewer heart attacks

#DZHK

Dangerous deposits in the blood vessels, known as plaques, pose a risk of heart attacks or strokes. In collaboration with international partners, a DZHK research team has now been able to show that certain genes influence the stability of plaques and thus the risk of cardiovascular disease. The study was published in the journal Arteriosclerosis, Thrombosis, and Vascular Biology.

2024-08-15

New Insights into the Risk of Heart Attack in Stroke Patients

#DZNE #DZHK

Study sheds light on the interaction of brain and heart. In stroke patients, the so-called troponin marker helps to assess the risk of an associated heart attack. This is a result of a joint study by DZNE and the DZHK, The findings could pave the way for better treatment.

2024-08-07

Hepatitis B: Liver cells switch off the immune response

#DZIF

An international team led by DZIF scientists has discovered that cells in blood vessels in the liver start a kind of ‘sleep timer’ that switches off immune cells after a certain period of time. Targeting this mechanism could be a starting point for immunotherapies for chronic hepatitis B.

2024-07-30

2nd DZG Munich Day: Working together to move more quickly from bench to bedside

More than 170 researchers and clinicians from all eight DZGs and invited guests from the world of politics shared insights on current DZG research projects at the 2nd DZG Munich Day in Munich on July 12, 2024.

2024-07-29

Weight Loss Influences Risky Decisions in Obesity

#DZD

Scientists from the DZD partner DIfE have now investigated whether massive weight loss in people with sever overweight (obese) leads to an improvement in metabolic and psychological states and whether decision-making is improved. The results were published in the journal Clinical Nutrition.

2024-07-23

How research aims to reduce mental disorders in children and adolescents: DZPG focuses on risk factors

#DZPG

Up to 20 percent of children and adolescents in Germany suffer from a mental disorder with different hazard potentials. At the DZPG, research is being conducted on many projects specifically for groups affected by risk factors aiming for earlier diagnosis and a broad network of prevention and support services for all ages.

2024-07-16

Iron-boost for the body's defense against cancer

#DZL

Immune cells are better able to keep lung tumors in check if they have previously been supplied with iron nanoparticles. This is shown by a project funded by the DZL partner Translational Lung Research Center Heidelberg.

2024-07-09

2nd DZG Munich Day: Together against common diseases

At the 2nd DZG Munich Day on July 12, 2024, the eight DZG in Munich will provide an overview of scientific highlights and an insight into joint research. Other focal points include the participation of patients and the presentation of poster awards.

2024-07-05

Project start for translational, cross-DZG research project in Dresden

#DZD #DKTK #DZNE

Scientists from the German Centers for Health Research (DZG) are competing with the aim of optimizing the translation of research results for application in patients and thus significantly improving the prevention and treatment of these diseases.

2024-07-01

A new precise tool for cardiac research

#DZHK

A new tool for the targeted modification of gene activity in heart muscle cells could establish itself as a standard method for research into cardiovascular diseases. A team of researchers from the German Center for Cardiovascular Research (DZHK) has successfully used the CRISPRi system to temporarily suppress gene expression in the heart muscle cells of mice without altering the genetic material.

2024-06-28

National Strategy for Gene and Cell Therapies opens up new perspectives for patients

On June 12, 2024, a joint strategy paper "National Strategy for Gene and Cell Therapies" was presented to Federal Research Minister Bettina Stark-Watzinger. It was conceived by stakeholders from science, industry, politics, authorities, foundations, patient organizations and with the participation of the German Centres for Health Research.

2024-06-20

Food in sight? The liver is ready!

#DZD

A research team from the DZD and the Max Planck Institute for Metabolism Research has shown in mice that the sight of food causes adaptations in the liver after just a few minutes. The results, which are published in the journal Science, could open up new ways of treating the widespread disease type 2 diabetes.

2024-06-11

Memory Self-Test via Smartphone Can Identify Early Signs of Alzheimer’s disease

#DZNE

A digital approach should pave the way for better early diagnosis of Alzheimer's disease. Researchers from Germany and the USA, with the involvement of the DZNE, have shown that memory problems can be detected using an app. The study results were published in the scientific journal npj Digital Medicine.

2024-06-04

Physical activity can counteract the negative effects of being alone

#DZPG

Social isolation and loneliness are a major social problem. Their negative impact on mental health has been worsen worldwide by the Covid-19 pandemic. An interdisciplinary team of researchers, including scientists from the DZPG, has investigated the extent to which physical activity can mitigate these negative effects. The results of the study were published in the journal Nature Mental Health.

2024-06-01

German Center for Paediatric and Adolescent Medicine enters the start-up phase as the new German Center for Health Research

#DZKJ

The German Center for Paediatric and Adolescent Medicine (DZKJ) will become a new DZG partner from June 1, 2024. This expands the circle to eight German Centers for Health Research. The DZG were established on the initiative of the Federal Ministry of Education and Research (BMBF).

2024-05-22

Monitoring treatment response in lung cancer patients with glycodelin

#DZL

A DZL research team has discovered that the presence of the protein glycodelin in the blood indicates that a lung cancer therapy has failed. This leads to interesting study results that have now been published in the journal Translational Research.

2024-05-14

Mechanism of action of the hepatitis B and D virus cell entry inhibitor bulevirtide deciphered

#DZIF

Over 12 million people worldwide suffer from a chronic infection with the hepatitis D virus. An international research team has now succeeded in deciphering the molecular structures of the transport proteins involved in virus entry. The research results, published in the renowned journal Nature Communications, pave the way for more targeted and effective treatment of chronically infected patients.

2024-05-08

Next milestone in the treatment of liver tumors and acute and chronic liver diseases

#DKTK

The results of a study conducted at the DKTK partner site in Tübingen give reason to hope that a newly developed drug could start a new era in oncological liver surgery and liver transplantation. The results of the study have now been published in the renowned scientific journal Cell.

2024-04-29

Bonn researchers aim to measure intricate brain structures with artificial intelligence

#DZNE

One million US dollars for AI-supported mapping of brain structures. A team of researchers at the DZNE in Bonn has received significant funding for the development of an innovative method based on artificial intelligence (AI) that will make it possible to measure the choroid plexuses in the human brain in three dimensions.

2024-04-23

Anabolic steroid use can increase heart disease risk

#DZHK

Taking androgenic anabolic steroids may increase the risk of atrial fibrillation in people with an existing predisposition as shown by the results of a new study published in the Journal of Physiology,

2024-04-16

6th Joint Dresden DZG Symposium brings together a variety of Dresden researchers once again

#DZNE #DZD #DKTK

The 6th Joint Dresden DZG Symposium on March 26, 2024 once again bring together a large number of researchers from the three German Centers for Health Research (DZG) located in Dresden.

2024-04-15

Kallistatin contributes to the beneficial metabolic effects of weight loss

#DZD

In a recent study, researchers at the DZD were able to show that people who are overweight or obese produce more of the protein kallistatin in the subcutaneous fatty tissue after losing weight. Kallistatin improves the metabolism and could open up new therapeutic options for people with obesity and type 2 diabetes in the future. The results have now been published in Molecular Metabolism.

2024-04-10

Hopeful Outlook: New Approach to Reduce Asthma Risk in Children

#DZL

A significant advancement in the research of childhood asthma was achieved by an interdisciplinary researcher group of the DZL, led by Helmholtz Munich and the Technical University of Munich (TUM). The study demonstrates a correlation between a specific gene variant in children and the development of asthma and opens new avenues for therapeutic approaches.

2024-04-03

First DZG Heidelberg-Mannheim Day brings together 150 representatives from six DZGs

#DZHK #DZPG #DZD #DKTK #DZIF #DZL

150 representatives from the six German Centers for Health Research (DZG) from the partner sites in Heidelberg and Mannheim met on February, 28 2024 on the first DZG Heidelberg-Mannheim Day. Overview presentations gave participants an insight into translational highlights of all individual DZGs and poster presentations and a panel discussion provided further opportunities to strengthen their networking and cooperations.

2024-03-26

Why does depression lead to learning disorders?

#DZPG

Findings of a study conducted over several months by a team led by DZPG neuroscientist Prof. Dr. med. Markus Ullsperger (University Magdeburg) together with colleagues from the University Clinic for Psychiatry and Psychotherapy and the German Center for Mental Health show a link between mental illness and cognitive deficits.

2024-03-20

Inhalation of a peptide in the fight against heart failure

#DZHK

Heart failure affects millions of people worldwide and the search is still on for a drug that can help patients in the long term. A new study by cardiologist PD Dr Alessio Alogna (Deutsches Herzzentrum der Charité Berlin and DZHK partner site Berlin) has provided the first data on peptide transport from the lungs to the heart using nano-in-micro technology (LungToHeartNiM technology). The study was recently published in the Journal of the American College of Cardiology (JACC).

2024-03-12

Joint success in rare gastrointestinal cancer

#DKTK

How can gastrointestinal stromal tumors (GIST) be treated and new therapies developed? For more than ten years, oncologists in Essen and drug researchers in Dortmund have been battling the rare gastrointestinal cancer GIST. Their latest results have now been published in the Journal of Clinical Oncology and in Nature Communications.

2024-02-21

Epstein-Barr Virus: Molecular Mechanism of Lymphoma Development Elucidated

#DZIF

In a recent study, a DZIF research team at Helmholtz Zentrum München has deciphered the molecular basis for the development of lymphomas caused by the Epstein-Barr virus (EBV) and thus identified a new target structure for the development of anti-EBV drugs.

2024-02-14

For an open and democratic society

DZG support statement by the Alliance of Science Organizations

The wave of protests against right-wing extremism, with demonstrations in many different locations in Germany, has been going on for […]

2024-02-14

How the body repairs lung tissue after viral pneumonia

#DZL

An international research team from the DZL, led by Lung Research of Giessen, has discovered a new repair mechanism with therapeutic potential. The work has now been published in "Nature Communications".

2024-01-12

Research for a healthy psyche: New German Centre for Health Research

#DZPG

The German Centre for Mental Health (DZPG) is another German Centre for Health Research (DZG). This brings the number of DZGs to seven: The aim of the German Centres for Health Research is to combat widespread diseases more effectively. The DZGs were established on the initiative of the BMBF.

2023-12-01

Epigenetically acting drugs could support cancer immunotherapy

#DKTK

Epigenetically active drugs enable the cell to read parts of the genome that were previously blocked and inaccessible. This leads to the formation of new mRNA transcripts and also new proteins. These "therapy-induced epitopes" could help the immune system recognize cancer cells.

2023-11-24

Atherosclerosis: RNA fragment creates prospect for new therapies

#DZHK

Researchers at the DZHK partner site in Munich have demonstrated for the first time what role a specific microRNA plays in atherosclerosis and how to intervene in this signaling pathway. As their next translational step, they plan to evaluate their results in larger animal models within the framework of the DZHK and the Cluster for Nucleic Acid Therapeutics Munich (CNATM).

2023-11-16

Blood - one of the most important marker in medical diagnostics

SYNERGIE #2 | 2023 published

The new issue of the SYNERGIE, the DZG's research magazine, is all about blood and blood counts. Find out more about the numerous and important functions of blood in our body and why blood counts have become indispensable for medical diagnostics.

2023-10-18

DZG presented career opportunities in translational medical research at the Annual GAIN conference in the U.S.

#DZHK #DZNE #DZD #DKTK #DZIF #DZL

The German Centers for Health Research (DZG) presented career opportunities in translational medical research at the annual conference of the […]

2023-08-10

Inhalation drug prevents severe pneumonia

#DKTK #DZL #DZIF

Researchers at the Technical University of Munich (TUM) have developed an RNA agent for a lung spray that slows down overactive macrophages to prevent severe lung damage. A new, sugar-based transport mechanism is especially effective in bringing the therapeutic to its target.

2023-07-25

1st DZG Munich Day brings together researchers of all eight DZG at the Munich site

#DZHK #DZNE #DZD #DKTK #DZIF #DZL #DZPG #DZKJ

On the first DZG Munich Day, scientists from all eight DZGs in Munich met to gain an overview of the structures and scientific highlights of the individual DZGs and an insight into DZG-wide cooperation.

2023-07-21

DZNE reinforces its study resources at several sites

#DZNE

The DZNE is expanding its nationwide clinical research infrastructure at several sites to increase treatment trial capacity and advance the development of drugs for neurodegenerative diseases.

2023-07-14

First Integrated Single-Cell Atlas of the Human Lung

#DZL

DZL researchers at Helmholtz Munich and an international team have taken up this challenge and developed the "Human Lung Cell Atlas" as the first single-cell atlas of a large organ.

2023-07-11

Project start for two translational, DZG-overarching research projects in Dresden

#DKTK #DZD #DZNE

Scientists of the German Centers for Health Research (DZG) compete with the aim of optimising the translation of research results for application to patients and thus significantly improving the prevention and treatment of these diseases.

2023-06-30

Translational medical research in focus at the DZG Science & Career Day 2023

#DZHK #DZNE #DZD #DKTK #DZIF #DZL

The first joint DZG Science & Career Day on the topic of "Translational Medical Research" at the Urania in Berlin brought together many young scientists from the different DZG and gave important impuls for their own career development.

2023-06-28

New vascular and cardiac research alliance between Berlin, Heidelberg and Mannheim

#DZHK

The newly founded HI-TAC Institute will research the communication of cells of the cardiovascular system with other organs. The DZHK is a partner in the new research alliance.

2023-06-07

Social contact strengthens dementia patients and can improve disease progression

Study on treatment and care for people with dementia published

An estimated 1.8 million people in Germany live with dementia. A recent study showed that if they are cared for in their familiar environment and are socially integrated, they show better disease progression.

2023-05-11

New functions discovered for wellknown cancer driver

Cancer of the pancreas still has an extremely poor prognosis: A certain so-called transcription factor dramatically accelerates growth - and can possibly be slowed down by targeted agents.

2023-05-04

5th Joint Dresden DZG Symposium unites researchers

#DKTK #DZNE #DZD

More than 100 scientists from Dresden exchanged views on commonalities in research on diabetes, cancer and neurodegenerative diseases.

2023-04-28

Epstein-Barr virus: First details on possible vaccine presented

An estimated 90 percent of the world's population is infected with EBV.

A whole range of diseases such as cancer or multiple sclerosis can be caused by the Epstein-Barr virus - EBV for short. A vaccine could prevent this in the future.

2023-04-24

Matthias Tschöp Wins Major US Award

Obesity and Diabetes Drugs Discovered

Matthias Tschöp is the first German to win the Banting Medal, the highest award of the American Diabetes Association. It is named after the Nobel Prize winner Sir Frederick Banting, one of the discoverers of insulin.

2023-03-28

German Centers for Health Research support declaration on patient participation of the Health Research Forum

How cultural change can succeed

It is a unique process in German health research: 20 experts and patients have worked together on a roadmap to systematically expand active patient participation in medical research.

2023-03-20

Overcoming professional boundaries - DZG fund joint project on gene and cell therapy

DZG Innovation Fund: Funding awarded for the first time

This is what ideal medicine would look like: Doctors could specifically alter molecular processes in diseased cells in the body and thus causally cure patients.

2023-01-30

DZG Early career scientist symposium on cutting-edge single cell analyses

The six German Centers for Health Research (DZG) jointly organized a first symposium for early career scientists to discuss the cutting-edge developments and techniques of single cell analysis in research and medicine.

120 early career scientists working in clinical and basic research discussed with experts about single cell technologies and their application during the online event on 10-11th November 2022.

2022-12-15

Longevity Treatments Do Not Slow Aging

Three approaches with a reputation for slowing aging processes have proven largely ineffective. For their study, researchers developed a new method to measure aging, which accounts for the complexity of aging in organisms.

2022-09-21

More Brain Lesions in Senior Women than in Men of the Same Age

In women after menopause, the extent of certain brain lesions is larger than in men of the same age. DZNE researchers come to this conclusion based on the assessment of more than 3,400 adults as part of the Bonn Rhineland Study.

2022-08-04

Cancer patients receiving immunotherapy: no evidence of increased risk for severe immune complication after COVID-19 vaccination

Does COVID-19 vaccination increase the risk of cancer patients undergoing therapy with immune checkpoint inhibitors to suffer a dangerous immune complication known as a "cytokine release syndrome"? A team of Heidelberg physicians and scientists has now shown in a clinical study: Increased serum levels of the characteristic cytokines occur frequently in cancer patients, but clinically relevant cases of the dreaded syndrome were not observed. The result supports the current recommendation to vaccinate cancer patients against COVID-19, even under therapy with immune checkpoint inhibitors.

2022-06-20

Clinical Research Award for DZIF and DZL tuberculosis researchers

Prestigious research award goes to researchers from two DZGs

This year's Award for Clinical Research of the German Society of Pneumology and Respiratory Medicine (DGP) went to a group of three young researchers from two German Centers for Health Research.

2022-05-31

Obesity, diabetes and high blood pressure increase mortality from COVID-19

Data from the European case register LEOSS

Obesity, impaired blood glucose metabolism, and high blood pressure increase the risk of dying from COVID-19 in young and middle-aged people to a level mostly observed in people of advanced age.

2022-05-19

"Pacesetters in health research"

10 Years of DZG

Four of six German Centres for Health Research (DZG) celebrated their tenth anniversary today with a ceremony in Berlin and around 300 guests from the worlds of politics and science.

2022-04-24

The Immune System - Our Health Network

SYNERGIE issue 1/22 published

In the current issue of SYNERGIE - Research for Health, the research magazine of the DZG, everything revolves around the body's own defense system. Read about the impressive ways in which the immune system protects us against disease and how it sometimes overreaches in the task.

News

New Therapeutic Strategies for Pulmonary Fibrosis

New blood test for treating malignant melanoma: liquid biopsy could complement radiological diagnostics

3rd Long COVID Congress: Needs-based care for post-infectious diseases - a generational problem?

Smartphone-Assisted “Scavenger Hunt” Identifies People at Risk for Dementia

Influence of the gut microbiome on blood vessels and thrombosis

New vector vaccine against COVID-19 provides long-term protection

Brown fat: how cells generate heat by burning calories

One Drop of Blood for Many Diagnoses

How stigmatisation harms the psyche: The DZPG is researching ways to reduce stigma in society

New risk score for assessing the risk of asthma in children

Successful research in first comprehensive study of the genome and proteome

Stable plaques, fewer heart attacks

New Insights into the Risk of Heart Attack in Stroke Patients

Hepatitis B: Liver cells switch off the immune response

2nd DZG Munich Day: Working together to move more quickly from bench to bedside

Weight Loss Influences Risky Decisions in Obesity

How research aims to reduce mental disorders in children and adolescents: DZPG focuses on risk factors

Iron-boost for the body's defense against cancer

2nd DZG Munich Day: Together against common diseases

Project start for translational, cross-DZG research project in Dresden

A new precise tool for cardiac research

National Strategy for Gene and Cell Therapies opens up new perspectives for patients

Food in sight? The liver is ready!

Memory Self-Test via Smartphone Can Identify Early Signs of Alzheimer’s disease

Physical activity can counteract the negative effects of being alone

German Center for Paediatric and Adolescent Medicine enters the start-up phase as the new German Center for Health Research

Monitoring treatment response in lung cancer patients with glycodelin

Mechanism of action of the hepatitis B and D virus cell entry inhibitor bulevirtide deciphered

Next milestone in the treatment of liver tumors and acute and chronic liver diseases

Bonn researchers aim to measure intricate brain structures with artificial intelligence

Anabolic steroid use can increase heart disease risk

6th Joint Dresden DZG Symposium brings together a variety of Dresden researchers once again

Kallistatin contributes to the beneficial metabolic effects of weight loss

Hopeful Outlook: New Approach to Reduce Asthma Risk in Children

First DZG Heidelberg-Mannheim Day brings together 150 representatives from six DZGs

Why does depression lead to learning disorders?

Inhalation of a peptide in the fight against heart failure

Joint success in rare gastrointestinal cancer

Epstein-Barr Virus: Molecular Mechanism of Lymphoma Development Elucidated

For an open and democratic society

How the body repairs lung tissue after viral pneumonia

Research for a healthy psyche: New German Centre for Health Research

Epigenetically acting drugs could support cancer immunotherapy

Atherosclerosis: RNA fragment creates prospect for new therapies

Blood - one of the most important marker in medical diagnostics

DZG presented career opportunities in translational medical research at the Annual GAIN conference in the U.S.

Inhalation drug prevents severe pneumonia

1st DZG Munich Day brings together researchers of all eight DZG at the Munich site

DZNE reinforces its study resources at several sites

First Integrated Single-Cell Atlas of the Human Lung

Project start for two translational, DZG-overarching research projects in Dresden

Translational medical research in focus at the DZG Science & Career Day 2023

New vascular and cardiac research alliance between Berlin, Heidelberg and Mannheim

Social contact strengthens dementia patients and can improve disease progression

New functions discovered for wellknown cancer driver

5th Joint Dresden DZG Symposium unites researchers

Epstein-Barr virus: First details on possible vaccine presented

Matthias Tschöp Wins Major US Award

German Centers for Health Research support declaration on patient participation of the Health Research Forum

Overcoming professional boundaries - DZG fund joint project on gene and cell therapy

DZG Early career scientist symposium on cutting-edge single cell analyses

Longevity Treatments Do Not Slow Aging

More Brain Lesions in Senior Women than in Men of the Same Age

Cancer patients receiving immunotherapy: no evidence of increased risk for severe immune complication after COVID-19 vaccination

Clinical Research Award for DZIF and DZL tuberculosis researchers

Obesity, diabetes and high blood pressure increase mortality from COVID-19

"Pacesetters in health research"

The Immune System - Our Health Network